IN VITRO ANTIOXIDANT AND ANTICANCER ACTIVITY OF MACRANGA PELTATA LEAF EXTRACTS ON LUNG CANCER CELL LINES

Objective: To determine the phytochemical constituents, antioxidant and anticancer activities of Macranga peltata leaf extracts on A549 P 51 human lung cancer cell lines.
 Methods: Leaf sample was subjected to soxhlet extraction method screening done using different biochemical tests. The activity tested 2,2–diphenyl-1-picrylhydrazyl, ferric ion reducing power assay 2,2–azino bis 3–ethyl benzothiazoline–b–sulfonic acid assay. In vitro lines evaluated by (3-(4,5-dimethyl thiazole-2yl)-2,5–diphenyl tetrazolium bromide) MTT assay.
 Results: Phytochemical confirmed presence phytoconstituents like tannins, flavanoids, alkaloids, saponins, glycosides sugar. assays exhibited significant inhibiting activity. proliferation methanolic extract plant drug produced a cytotoxic effect with an IC50 value 197.10 µg/ml, while it had no normal Conclusion: It has been reported flavanoid characteristics in cancer. M. contains wide variety secondary metabolites that hold strong capacity. Their have found be potential source antioxidants